INDICATION

AGE CRITERIA

DESCRIPTION

Rheumatoid Arthritis (Registry)

≥ 18 yrs. old

Corrona Rheumatoid Arthritis (RA) Drug Safety & Effectiveness Registry

Rheumatoid Arthritis

≥ 18 yrs. old

*HOLD* A Randomized Controlled Pragmatic Phase 3b/4 Study of Bariticinib in Patients wih RA

Osteo Arthritis of the Knee

≥ 18 yrs. old

A 48-Week, Phase 2b/3a, Double-Blind, Randomized, Placebo Controlled, Multi-center, Superiority Study to Evaluate the Efficacy and Safety of Joint Stem, Autologous Adipose Tissue Derived Mesenchymal Stem Cells in patients diagnosed with Knee Osteoarthritis.

Systemic Lupus Erythematosus

18-70

A Phase 3 Study Evaluating the Efficacy and Safety of Subcutaneous Anifrolumab in Adult Subjects with Active Systemic Lupus Erythematosus.

Osteo Arthritis of the Knee

≥50 to ≤80

A randomized, two-arm, placebo -controlled, participant and investigator-blinded study investigating the efficacy, safety and tolerability of DFV890 in patients with symptomatic knee osteoarthritis.

Osteo Arthritis of the Knee

≥ 40 yrs old

Pending Amendment Approval (Tentative Mid Sept Star-up): A Randomized, Double-Blind, Placebo-Controlled, Multi-Center, Phase 3 Study to Determine the Efficacy of TG-C in Subjects with Kellgren and Lawrence Grade 2 or 3 Osteoarthritis of the Knee

Osteo Arthritis of the Knee

*STAGE 1 CLOSED, STAGE 2 to open in Q1 of

A 2-Stage, Adaptive, Randomized, Double-blind, Placebo-Controlled, Multicenter Study to Evaluate Dose and Treatment Effect of Pentosane Polysulfide Sodium Compared with Placebo in Participants with Knee Osteoarthritis Pain

Gout

≥18 and ≤65

A Phase 2B, Multicenter, Randomized, Double-blind, Placebo-controlled, Dose-finding Study with an Open-label Extension to Evaluate the Efficacy and Safety of 3 Dosages of SAP-001 in Combination with Standard of Care in Adult Subjects
with Gout, with or without Tophi, and Hyperuricemia Refractory to Conventional Xanthine

Eosinophilic Esophagitis

18 yrs old

A Randomized, Double-blind, Placebo-Controlled 24-Week Induction Study of APT-1011, followed by a Single-arm Open-label Extension, in Adult Subjects with Eosinophilic Esophagitis

Refractory Chronic Cough

18 – 80

Randomized, Double-Blind, Placebo-Controlled, Parallel-Arm Efficacy and Safety Study with Open label Extension of BLU-5937 in Adult Participants with Refractory Chronic Cough, Including Unexplained Chronic Cough (CALM-2)

Uncontrolled Hypertension

≥ 18 yrs old

A RANDOMIZED, DOUBLE-BLIND, PLACEBO CONTROLLED, PARALLEL ARM, MULTICENTER, PHASE 2 STUDY TO EVALUATE THE EFFICACY AND SAFETY OF LORUNDROSTAT IN SUBJECTS WITH UNCONTROLLED HYPERTENSION ON A STANDARDIZED MEDICATION REGIMEN

Rotator Cuff Tendinopathy

18-65

A randomized, parallel-group, 24 week, double-blind, placebo-controlled, multicenter Phase 3 study to assess the efficacy and safety of secukinumab compared to placebo in adult patients with active rotator cuff tendinopathy

Rheumatoid Arthritis

18-80

A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Assess the Safety, Pharmacokinetics, and Efficacy of KPL-404 in Subjects with Moderate to Severe, Active Rheumatoid Arthritis with Inadequate Response or Intolerance to at Least One Biologic Disease modifying Anti-rheumatic Drug or a Janus Kinase Inhibitor

INDICATION

AGE CRITERIA

DESCRIPTION

Discoid Lupus Erythematosus, Subacute Cutaneous Lupus Erythematosus, or Systemic Lupus Erythematosus

18-75

A Phase 1b, Randomized, Double-Blind, Placebo-Controlled, Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BMS-986326 in Adult Participants with Discoid Lupus Erythematosus, Subacute Cutaneous Lupus Erythematosus, or Systemic Lupus Erythematosus

Systemic Sclerosis

18 – 70

A Multicenter, Randomized, Parallel-group, Double-blind, Two-arm, Phase III Study to Evaluate the Safety and Efficacy of Anifrolumab Compared with Placebo in Male and Female Participants 18 to 70 Years of Age Inclusive with Systemic Sclerosis

Gout

18 – 85

A Randomized, Multi-regional, Double-blind, Double-dummy Parallel-group, Placebo and Allopurinol-Controlled Phase 3 Study to Assess the Efficacy and Safety of Tigulixostat in Gout Patients with Hyperuricemia

Rheumatoid Arthritis

≥ 18 yrs old

A Phase 1b, Randomized, Placebo-controlled, Multi-center Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Imvotamab in Participants with Moderate to Severe Rheumatoid Arthritis who have Failed Prior Therapies

Rheumatoid Arthritis

≥ 18 yrs old

Vectra InVolved Informed Decision Outcome Study (VIVID): A prospective randomized controlled trial evaluating the effect of guided care with Vectra compared to treatment as usual in patients with rheumatoid arthritis